Eosinophil chemotactic factor CCL8 affects host- Angiostrongylus cantonensis adaptation

การบรรยายพิเศษ เรื่อง “Eosinophil chemotactic factor CCL8 affects host- Angiostrongylus cantonensis adaptation”

โดย Prof. Zhiyue Lv, Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, China

ในวันศุกร์ที่ 29 เมษายน 2559 เวลา 11.00 – 12.00 น.
ณ ห้องประชุม VDO Conference ชั้น 5 อาคารเฉลิมพระเกียรติ คณะเวชศาสตร์เขตร้อน มหาวิทยาลัยมหิดล

On April 29th , Professor Zhiyue Lv, from the Zhongshan School of Medicine at the Sun Yat-sen University, China, held a lunch talk covering his recent study – “Eosinophil chemotactic factor CCL8 affects host–Angiostrongylus cantonensis adaptation”.

The rat lungworm Angiostrongylus cantonensis, a food-borne nematode parasite, is the primary cause of human eosinophilic meningitis, meningoencephalitis and other neurological disorders. To start his talk Prof Lv outlined his investigation of permissive hosts (rats) and non-permissive hosts (mice and humans) of the parasite. Through his research he hoped to be able to answer the question – why are outcomes for permissive and non-permissive hosts so different?.

Over the subsequent slides Prof Lv showed how it was found that CCL8, a non-permissive host-specific eosinophil chemotactic chemokine was responsible for the differing outcomes. Levels of CCL8 were high in the in central nerve system of A. cantonensis infected mice, a non-permissive host but not in rats, permissive hosts.

He then explained the next stage in the investigation – using anti-CCL8 monoclonal antibodies to further determine the role of CCL8 in host response to A. cantonensis infection. The investigation found that deletion of CCL8 contributes to larvae migration from brain to lung and adult development of A.cantonensis in permissive hosts and determines host-A. cantonensis adaption.

Prof Lv finished his talk with a few words on the importance of building international cooperation to help fight diseases. He invited researchers to contact him to look into the possibility of working with him or with his colleagues at Sun Yat-sen University. We thank Prof Lv again for his time and commitment and we hope to see him again soon.

Narrator : Ms. Nicola Ball

Download: 1. Lunch Talk – 29-4-2016

2. Eosinophil chemotactic factor CCL8 affects host- Angiostrongylus cantonensis adaptation


Talk 29April


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